Rau cov kws kho mob uas xyaum ua pov thawj-raws li thiab kev siv tshuaj sib xyaw ua ke, Hloov Kho Citrus Pectin (MCP) sawv cev rau tus qauv tshiab rau kev txhawb nqa. Thaum pectin tau dav paub tias yog cov khoom noj muaj fiber ntau, MCP qhov tshwj xeeb nyob hauv nws cov qauv hloov pauv tshwj xeeb, uas ua rau nws hla txoj hnyuv thiab nkag mus rau hauv lub cev, tso cai rau kev kho mob hnyav.1Qhov no txawv ntawm pectin zoo tib yam thiab muaj txoj hauv kev tshiab rau kev tswj hwm ntawm ntau yam mob.
Core Mechanism: Antagonism ntawm Galectin-3
Lub hauv paus txheej txheem ntawm kev txiav txim rau MCP yog nws cov kev tawm tsam tshwj xeeb ntawm galectin-3 (Gal-3).1Gal-3 yog cov protein uas ua lub luag haujlwm tseem ceeb hauv cellular proliferation, adhesion, migration, thiab inflammatory teb.3Nws overexpression yog txuas mus rau ntau yam pathological xeev, xws li mob cancer metastasis, organ fibrosis, thiab mob o.1MCP, uas yog nplua nuj nyob rau hauv galactoside residues, ua raws li kev sib tw ligand rau Gal -3, zoo khi rau nws cov carbohydrate-paub qhov chaw (CRD) thiab yog li inhibiting Gal-3 muaj nuj nqi.4Los ntawm cov txheej txheem no, MCP tuaj yeem cuam tshuam ntau yam txheej txheem pathophysiological.
Preclinical thiab Clinical Evidence Review
Cov teebmeem ntawm MCP tau raug lees paub hauv ntau qhov kev tshawb fawb:
Adjunctive Cancer Care: Kev tshawb fawb qhia tau hais tias MCP tuaj yeem hloov kho qhov metastatic cascade los ntawm inhibiting ntau tus nqi - txwv cov kauj ruam, xws li mob qog noj ntshav, adhesion, thiab angiogenesis.4Kev tiv thaiv - cov teebmeem metastatic tau pom nyob rau hauv vitro thiab tsiaj qauv ntawm lub mis, txoj hnyuv, melanoma, thiab qog nqaij hlav prostate.4Hauv kev tshawb fawb soj ntsuam ntawm cov neeg mob qog noj ntshav prostate, kev ntxiv nrog MCP tau cuam tshuam nrog lub sijhawm ntev prostate -cov tshuaj tiv thaiv tshwj xeeb (PSA) ob zaug hauv 7 ntawm 10 tus neeg mob, nrog rau 4 tus neeg mob qhia tias nce ntau dua 30%.4Qhov kev ncua ntev ntawm PSA ob npaug ntawm lub sijhawm yog ib qho kev kho mob qhia txog kev mob qeeb zuj zus.
Heavy Hlau Chelation: MCP tau pom zoo los txhawb txoj kev tso zis ntawm cov hlau hnyav xws li txhuas thiab cadmium yam tsis cuam tshuam qhov sib npaug ntawm cov khoom tseem ceeb xws li calcium, zinc, thiab magnesium.4Qhov no ua rau nws muaj peev xwm muaj kev nyab xeeb thiab tsis yog -kev xaiv rau kev tshem tawm cov hlau hnyav.4
Immune Modulation: MCP kuj qhia txog kev ua immunomodulatory. Cov kev tshawb fawb tau pom tias nws tuaj yeem txhim kho cov qib pro- mob cytokines (xws li IL-17, IFN- , thiab TNF- ), qhia tias nws yuav muaj txiaj ntsig zoo los ntawm kev ua kom lub cev tiv thaiv kab mob.6Cov kev tshawb pom no muab lub hauv paus theoretical rau kev siv MCP hauv kev tiv thaiv kab mob.
Kev tsim khoom thiab kev ruaj ntseg zoo: Ua kom muaj kev ntseeg siab rau kev siv tshuaj kho mob
Rau cov kws kho mob, qhov zoo, purity, thiab sib xws ntawm cov tshuaj yog qhov tseem ceeb. Zhejiang Kub Kropn Biotechnology Co., Ltd. muab kev ruaj ntseg zoo hauv qhov no.
Zhejiang Kub Kropn Biotechnology Co., Ltd. yog lub teb chaws siab -tech enterprise integrating scientific research, ntau lawm, thiab muag khoom. Hauv kev koom tes nrog cov tsev kawm ntawv qib siab xws li Zhejiang University, Fudan University, Tianjin University, thiab Xinxiang Medical University hauv Henan, lub tuam txhab nquag ua kev tshawb fawb ntawm cov khoom noj khoom haus hloov kho citrus pectin (MCP), thiab nws cov khoom raug xa tawm mus rau ntau lub teb chaws thiab cheeb tsam thoob ntiaj teb. Lub tuam txhab ua haujlwm 100,000-qib GMP- muaj ntawv pov thawj cov chaw tsim khoom, siv cov txiv qaub tev tawm los ua cov khoom siv raw thiab siv cov thev naus laus zis enzymatic hydrolysis kom tshem tawm siab -purity MCP. Txhua kauj ruam ntawm cov txheej txheem-los ntawm kev xaiv raw khoom mus rau ntau lawm-yog tswj nruj me ntsis. Lub tuam txhab ua raws li cov khoom xyaw ntuj thiab cov txheej txheem tsim khoom kom huv si kom paub meej cov khoom muaj kev nyab xeeb thiab zoo tshaj plaws.
Nws 100,000-qib GMP-tso ntawv pov thawj cov chaw tsim khoom yog qhov ua pov thawj muaj zog rau cov khoom lag luam zoo thiab kev nyab xeeb.9Qib ntawv pov thawj no qhia tau hais tias qhov chaw tsim khoom thiab cov txheej txheem ua tau raws li cov qauv nruj zoo ib yam li cov kev tsim tshuaj, ua kom muaj kev huv huv thiab cov khoom sib xws-rau-batch sib xws ntawm cov khoom- lub hauv paus tseem ceeb ntawm kev ntseeg siab rau kev pom zoo ib qho kev pab kho mob hauv chaw kho mob.
Xaus thiab yav tom ntej Outlook
Raws li kev nyab xeeb thiab zoo- noj zaub mov ntxiv, MCP cov teebmeem pleiotropic los ntawm Gal-3 antagonism qhia tau hais tias muaj peev xwm tseem ceeb hauv kev kho mob qog noj ntshav, hnyav hlau detoxification, thiab kev tiv thaiv kab mob. Nws muab cov kws kho mob thiab cov neeg mob muaj peev xwm tshawb nrhiav ntau yam kev daws teeb meem kev noj qab haus huv ntau dua li cov kev kho mob ib txwm muaj. Raws li kev tshawb fawb ntau ntxiv, MCP tau npaj los ua lub luag haujlwm tseem ceeb hauv kev ua haujlwm pab kho mob yav tom ntej.
Peb txhawb kom cov kws kho mob hu rau peb rau kev sib tham txog cov kev siv ntawm Modified Citrus Pectin. Yog xav paub ntxiv, thov hu rau peb ntawm email: wilson@zjgykp.com.
Pleiotropic teebmeem ntawm Hloov Citrus Pectin - MDPI,https://www.mdpi.com/2072-6643/11/11/2619
Kev hloov pauv ntawm citrus pectin oligosaccharide thauj hla Caco-2 cell monolayers,https://www.researchgate.net/publication/257746057_Profiling_of_modified_citrus_pectin_oligosaccharide_transport_across_Caco-2_cell_monolayers
Demystifying Modified Citrus Pectin: Dab tsi yog Pov Thawj? - Lub koom haum Metagenics,https://www.metagenicsinstitute.com/blogs/demystifying-hloov-citrus-pectin-evidence/
Tawm tsam Cancer Metastasis thiab Heavy Hlau Toxicities Nrog Hloov Citrus Pectin,https://www.lifeextension.com/magazine/2009/3/modified-citrus-pectin-fighting-cancer-metastasis-heavy-metal{11}}toxicities
Pectin: Siv thiab Risks - WebMD,https://www.webmd.com/vitamins-thiab-supplements/pectin- siv-thiab-risks
Immunomodulatory nyhuv ntawm ntuj thiab hloov Citrus pectin ntawm cytokine ntau ntau nyob rau hauv tus po ntawm BALB/c nas - PubMed,https://pubmed.ncbi.nlm.nih.gov/30292091/
Khoom noj khoom haus: Cov txiaj ntsig thiab kev nyab xeeb ceev faj - HelpGuide.org,https://www.helpguide.org/wellness/nutrition/dietary-supplements
Lub ntsiab lus ntawm kev hloov kho citrus pectin ntxiv - NCI Phau Ntawv Qhia Tshuaj,https://www.cancer.gov/publications/dictionaries/cancer-drug/def/modified-citrus-pectin- ntxiv
Qhov Tseeb Txog Kev Ua Haujlwm Zoo Tam Sim No (CGMP) - FDA,https://www.fda.gov/drugs/pharmaceutical-zoo-resources/facts-txog-tam sim no-zoo-kev tsim khoom- xyaum-cgmp
Kev Ua Haujlwm Zoo - Cornell CALS,https://cals.cornell.edu/dairy-extension/what-peb-do/food-kev nyab xeeb-resources/good-manufacturing-kev coj ua
Nkag siab Tus Neeg Mob Preference rau Kev Kho Mob Kev Kho Mob: Cov txiaj ntsig los ntawm Pab Pawg Saib Xyuas Neeg Mob - PMC - PubMed Central,https://pmc.ncbi.nlm.nih.gov/articles/PMC2219802/
Ntuj pab thiab tus neeg mob txoj kev xav|MDEdge - Tus Kws Kho Mob,https://community.the-hospitalist.org/content/natural-supplements-thiab-cov neeg mob- foundations
Hloov Kho Citrus Pectin Monograph - Hloov Tshuaj Ntsuam Xyuas,https://altmedrev.com/wp-content/uploads/2019/02/v5-6-573.pdf
Tshuaj ntsuab thiab noj zaub mov ntxiv - LiverTox - NCBI Bookshelf,https://www.ncbi.nlm.nih.gov/books/NBK548441/
Lub luag haujlwm muaj peev xwm ntawm Hloov Pectin Targeting Galectin-3 tiv thaiv tus mob ua pa hnyav Coronavirus-2 - MDPI,https://www.mdpi.com/2571-8800/4/4/56
Hloov kho citrus pectin anti-metastatic zog: ib lub mos txwv, ntau lub hom phiaj - PMC,https://pmc.ncbi.nlm.nih.gov/articles/PMC2782490/
tshuaj tiv thaiv- cawv los ntawm kev hloov pauv pectin.pdf