Ib tus kws kho mob tshuaj xyuas ntawm Hloov Pectin Powder: Kev Nyab Xeeb, Tshuab, thiab Cov Ntawv Siv Muaj Peev Xwm

Kev ntsuam xyuas Novel Prebiotic rau Kev Kho Mob

Kev sib koom ua ke ntawm cov pov thawj-raws li cov khoom noj khoom haus ntxiv rau hauv kev kho mob yuav tsum muaj kev ntsuam xyuas zoo ntawm lawv cov kev nyab xeeb, kev ua haujlwm, thiab cov kev siv tau. Qhov kev tshuaj xyuas no muab cov txheej txheem kho mob ntawm Hloov Kho Citrus Pectin (MCP), kuj raug xa mus rau hauv cov ntaub ntawv tshawb fawb xws li Pectin- muab tau los ntawm Acidic Oligosaccharides (PAOS), raws li kev soj ntsuam kev nyab xeeb uas luam tawm hauvRegulatory Toxicology thiab Pharmacology.¹MCP/PAOS yog ib qho qis -molecular- hnyav, tsis yog - carbohydrates digestible tau los ntawm cov zaub mov- qib pectin ntawm enzymatic hydrolysis. Nws tau raug tshawb xyuas rau nws cov khoom siv raws li cov khoom siv prebiotic hauv kev noj zaub mov tshwj xeeb, suav nrog cov zaub mov kho mob.¹

Mechanism of Action: Colonic Fermentation thiab Systemic Effects

Lub luag haujlwm tseem ceeb ntawm kev ua haujlwm rau MCP yog qhov ntawm prebiotic fiber. Vim nws cov qauv tshuaj, nws tiv thaiv digestion thiab hydrolysis nyob rau hauv lub plab thiab cov hnyuv, mus txog loj heev nyob rau hauv txoj hnyuv.¹Yog li ntawd nws tsis yog suav tias yog muaj nyob rau hauv nws daim ntawv qub.¹Nyob rau hauv txoj hnyuv, MCP yog xaiv fermented los ntawm cov neeg nyob hauv microbiota, ua rau cov tiam luv luv -chain fatty acids (SCFAs) xws li butyrate, propionate, thiab acetate.¹

Cov SCFAs no ua rau muaj ntau yam teebmeem ntawm lub cev. Lawv ua lub zog tseem ceeb rau colonocytes, pab tswj lub plab noj qab haus huv, thiab cuam tshuam rau hauv zos thiab lub cev tiv thaiv kab mob. Cov txheej txheem fermentation kuj ua rau lwm yam zoo -cov ntaub ntawv cuam tshuam nrog fermentable fibers. Hauv cov qauv ua ntej, kev tswj hwm ntawm PAOS tau cuam tshuam nrog kev nce hauv caecum qhov hnyav, kev hloov kho lub cev rau siab - fiber ntau noj, nrog rau kev txhim kho plab hnyuv calcium.¹Tsis tas li ntawd, ua raws li cov kev cuam tshuam ntawm metabolic ntawm fermentable carbohydrates, txiv neej nas noj 10% PAOS noj zaub mov pom zoo txo ​​qis hauv cov roj cholesterol, phospholipids, thiab triglycerides.¹

Comprehensive Toxicological thiab Genotoxicity Profile

Lub roj teeb dav dav ntawm kev tshawb fawb txog kev nyab xeeb tau ua tiav ntawm PAOS. Cov tshuaj tau pom tias tsis yog -mutagenic hauv cov kab mob rov qab hloov pauv (Ames test).¹Thaum ib txhia

hauv vitromammalian cell gene mutation thiab chromosomal aberration assays yielded equivocal or positive results, cov no tau pom tsuas yog nyob rau hauv siab cytotoxic concentrations thiab nyob rau hauv tsis muaj metabolic activation.¹Kev tshawb nrhiav ntxiv tau nthuav tawm tias cov kev tshawb pom no yuav yog cov khoom cuav ntawm qhov kev sim, raws li nws paub tias cov teebmeem cytotoxic tuaj yeem ua rau muaj qhov tsis zoo hauv qhov kev ntsuam xyuas.¹Thaum PAOS raug tshem tawm hauv kab lis kev cai nruab nrab es tsis txhob siv DMSO, cov teebmeem clastogenic tau pom tsuas yog nyob rau qib siab tshaj plaws pom zoo nrog cytotoxicity siab, ua rau cov txiaj ntsig tsis cuam tshuam txog kev lom neeg.¹

Qhov tseem ceeb, cov nohauv vitrokev txhawj xeeb tsis tau lees paub los ntawmhauv vivo testing. In a micronucleus test conducted as part of a sub-chronic study in rats, dietary administration of PAOS at high doses (>7 g / kg bw / hnub) rau 13 lub lis piam tsis ua rau chromosomal puas los yog puas rau lub mitotic apparatus nyob rau hauv cov pob txha hlwb.¹Qhov no meej tsis zoo

hauv vivoQhov tshwm sim, uas ntsuas cov compound thiab nws cov metabolites nyob rau hauv physiological mob, muab pov thawj muaj zog rau qhov tsis muaj genotoxic peev xwm.

Deconstructing Urothelial Hyperplasia Nrhiav nyob rau hauv nas

Cov sub-kev tshawb fawb nas mob tau sau tseg txog kev kho mob- cuam tshuam txog kev hloov pauv hauv cov zis hauv lub zais zis, tshwj xeeb tshaj yog diffuse yooj yim urothelial hyperplasia, hauv cov tsiaj noj 10% PAOS.¹Kev tshawb nrhiav kev tshawb fawb zoo tau ua tiav los txiav txim qhov ua rau. Qhov kev tshawb pom tau cuam tshuam nrog kev nce ntxiv hauv cov zis pH thiab cov zis sodium concentration, uas tau sau tseg rau cov ntsiab lus sodium siab (3.1%) ntawm PAOS cov khoom siv es tsis yog cov khoom siv oligosaccharide nws tus kheej.¹Qhov tshwm sim no yog qhov zoo- sau tseg, hom- cov lus teb tshwj xeeb hauv nas thiab tsis nquag pom hauv lwm hom.¹

Txhawm rau txheeb xyuas cov txheej txheem no, kev tshawb fawb ntxiv tshuab tau ua. Ib pawg nas tau txais 10% PAOS noj zaub mov ntxiv nrog ammonium chloride (NH4 Cl), tus neeg ua haujlwm acidifying. Thaum cov pab pawg tau txais 10% PAOS ib leeg rov pom qhov tshwm sim ntawm urothelial hyperplasia, qhov qis pH ntawm cov zis tshwm sim los ntawm NH4​Cltag nrho tiv thaiv kev loj hlob ntawm urothelial hyperplasianyob rau hauv pawg ua ke.¹Txoj kev tshawb no elegantly tsim tau lees paub tias cov nyhuv tsis yog vim PAOS

rau se, tab sis rau qhov tshwj xeeb urinary tej yam kev mob ntawm high sodium thiab siab pH nyob rau hauv tus qauv nas. Cov txheej txheem no-induced hyperplasia nyob rau hauv nas yog suav hais tias tsis muaj feem xyuam rau tib neeg, uas nws cov zis pH feem ntau yog acidic.¹

Tsim Kev Nyab Xeeb Hauv Tib Neeg thiab Tsis Muaj - Pom Zoo - Tsis Zoo - Qib Siab (NOAEL)

Raws li cov ntaub ntawv qhia ua ntej, Tsis muaj-Saib xyuas-Adverse-Txoj Kev Teeb Meem (NOAEL) rau cov nas raug tsim los ntawm kev noj zaub mov ntawm 2.5% PAOS, sib npaug rau 1.7 g / kg lub cev hnyav / hnub.¹Cov theem no yog kwv yees li 8.5 mus rau 11 npaug siab dua li qhov xav tau txhua hnub rau cov menyuam mos thiab cov neeg laus, raws li, muab cov txiaj ntsig zoo ntawm kev nyab xeeb.

Kev nyab xeeb ntawm PAOS tau txais kev txhawb nqa ntxiv los ntawm tib neeg cov ntaub ntawv. Ib txoj kev tshawb fawb hauv pre-cov me nyuam mos lub sij hawm qhia tau hais tias ntxiv nrog PAOS tsis cuam tshuam rau cov zis pH.¹Tsis tas li ntawd, kev tshawb fawb 12-lub lim tiam hauv HAART- tsis zoo HIV- cov neeg laus tau kis tau pom tias kev tswj hwm ntawm 18 g / hnub tau txais txiaj ntsig zoo, tsis muaj qhov cuam tshuam tsis zoo thiab tsis muaj kev hloov pauv hauv daim siab lossis lub raum ua haujlwm.¹

Rau cov kws kho mob txiav txim siabhloov pectin hmoovrau lawv cov neeg mob, nrhiav los ntawm lub koob npe nrov, kev tshawb fawb- tsav cov chaw tsim khoom yog qhov tseem ceeb. Zhejiang Kub Kropn Biotechnology Co., Ltd. yog ib tug thawj coj nyob rau hauv daim teb no, kev khiav hauj lwm raws li lub teb chaws siab -tech enterprise nrog muaj zog ties rau kev kawm ntawv cov tsev kawm ntawv xws li Zhejiang University thiab Fudan University. Lawv txoj kev mob siab rau kev ua tau zoo yog pom los ntawm lawv cov 100,000- qib GMP-certified facility thiab lawv siv cov tshuab enzymatic hydrolysis siab heev, ua kom cov khoom muaj purity siab thiab sib xws uas haum rau kev soj ntsuam xyuas. Rau kev nug txog kev kho mob lossis cov ntaub ntawv ntawm kev muab, hu rau wilson@zjgykp.com.

Xaus rau Tus Kws Kho Mob

Hloov Kho Citrus Pectin (PAOS) ​​yog ib qho dej zoo - tshawb fawb prebiotic nrog cov ntaub ntawv muaj kev nyab xeeb thiab muaj kev qhia meej meej ntawm kev ua haujlwm kho mob los ntawm lub plab microbiota. Kev tshawb fawb toxicological dav dav paub meej tias nws tsis muaj genotoxicityhauv vivo. Cov nas tsuag -Kev tshawb pom tshwj xeeb ntawm urothelial hyperplasia tau raug kho kom raug thiab tsis cuam tshuam rau tib neeg lub cev. Kev txhawb nqa los ntawm NOAEL siab thiab cov ntaub ntawv zoo rau tib neeg, MCP sawv cev rau kev nyab xeeb thiab pov thawj-raws li kev xaiv rau cov kws kho mob los txiav txim siab rau lub plab thiab kev tiv thaiv kab mob hauv lawv cov neeg mob.