Kev Ntsuam Xyuas Kev Kho Mob: Hloov Citrus Pectin raws li Galectin-3 Antagonist hauv Integrative Oncology

Bioavailable Polysaccharide nrog Kev Kho Mob Muaj Peev Xwm

Hloov Citrus Pectin (MCP) yog ib qho qis -molecular- hnyav polysaccharide muab tau los ntawm tev thiab pulp ntawm citrus txiv hmab txiv ntoo. Tsis zoo li cov pectin ib txwm muaj, cov khoom noj muaj fiber ntau nrog kev ua haujlwm tsawg, MCP tau dhau los ua cov txheej txheem ntawm enzymatic lossis pH / thermal hydrolysis. Cov txheej txheem no yields fragments nrog ib tug molecular hnyav ntawm tsawg tshaj li 15 kDa thiab ib tug℃ntawm esterification hauv qab no 5%.³Cov kev hloov kho cov qauv tseem ceeb no muab cov txheej txheem bioavailability raws li kev tswj hwm qhov ncauj, tso cai rau MCP ua haujlwm ua tus neeg sawv cev kho mob hauv kev ncig.³Nws qhov tseem ceeb thiab zoo tshaj plaws -tus yam ntxwv ntawm kev ua haujlwm yog kev sib tw inhibition ntawm Galectin-3, cov protein uas cuam tshuam rau kev mob qog noj ntshav thiab metastasis.⁵

Galectin-3: Ib Lub Hom Phiaj Ua Tau Zoo hauv Cov qog nqaij hlav thiab Metastasis

Galectin-3 (Gal-3), ib qho tshwj xeeb chimera- hom tswv cuab ntawm -galactoside-binding-binding lectin tsev neeg, yog lub hom phiaj kho tau zoo hauv oncology. Nws yog overexpressed nyob rau hauv ib tug dav array ntawm malignancies, xws li prostate, nyuv, mis, melanoma, thiab thyroid cancer.⁵Clinically, elevated circulating theem ntawm Gal-3 muaj kev sib raug zoo nrog lub xub ntiag ntawm tus kab mob metastatic thiab suav hais tias yog ib tug tsis zoo prognostic biomarker.²⁰

Lub luag haujlwm ntawm pathophysiological ntawm Gal-3 hauv oncogenesis yog pleiotropic. Nws txhawb txoj kev loj hlob ntawm qog nqaij hlav los ntawm ntau txoj hauv kev: ua kom yooj yim homotypic cell aggregation thiab heterotypic cell adhesion mus rau extracellular matrix thiab endothelium, conferring resistance to apoptosis (anoikis), txhawb angiogenesis, thiab modulating qog immune microenvironment.¹⁰Kev tshawb fawb tsis ntev los no tau piav qhia ntxiv txog nws cov txheej txheem, uas qhia tau hais tias cov kab mob nce siab ntawm kev ncig Gal -3 induce lub secretion ntawm metastasis-txhawb cytokines, xws li Interleukin-6 (IL-6), los ntawm vascular endothelium. Qhov no, nyob rau hauv lem, upregulates endothelial adhesion molecules, zoo priming nyob deb qhov chaw rau metastatic noob.²⁰Cov pov thawj no ruaj khov tsim Gal-3 ua tus tsav tsheb tseem ceeb ntawm metastatic cascade thiab lub hom phiaj raug cai rau kev cuam tshuam kev kho mob.

Mechanism of Action: Interrupting Metastatic Cascade

MCP, uas yog nplua nuj nyob rau hauv -galactose moieties, ua hauj lwm raws li ib tug siab -affinity ntuj ligand rau lub carbohydrate recognition domain (CRD) ntawm Gal-3.⁵Los ntawm kev khi rau ob qho tib si ncig thiab xov tooj ntawm tes -surface Gal-3, MCP sib tw ua rau nws cov kab mob pathological, cuam tshuam ntau yam kev txwv cov kauj ruam ntawm metastatic cascade:

Anoikis Resistance:Gal-3 tiv thaiv cov qog hlwb los ntawm apoptosis los ntawm inducing G1 cell voj voog ntes.⁵Cov pov thawj preclinical qhia tias MCP tuaj yeem tiv thaiv qhov kev tiv thaiv no, uas muaj peev xwm ua rau cov qog hlwb ntau dua rau anoikis.

Intravascular Adhesion thiab Aggregation:MCP ncaj qha thaiv Gal-3-mediated qog cell adhesion rau vascular endothelium thiab suppresses homotypic aggregation ntawm qog hlwb. Qhov kev ua ob no txo ​​qhov tsim ntawm qog emboli thiab inhibits lawv ntes nyob rau hauv cov kab mob microvasculature, ib kauj ruam tseem ceeb rau extravasation thiab colonization.¹¹

Angiogenesis:Gal-3 ua hauj lwm raws li ib tug chemoattractant rau endothelial hlwb thiab induces capillary raj tsim. MCP tau ua pov thawj los cuam tshuam qhov chemotaxis no thiab inhibit angiogenesis hauv vitro thiab hauv vivo, yog li txwv cov qog lub peev xwm los tsim cov ntshav.¹⁹

Kev tshuaj xyuas cov ntaub ntawv pov thawj kho mob thiab kev nyab xeeb profile

Kev siv tshuaj kho mob ntawm MCP tau raug tshawb xyuas hauv ntau qhov kev sim tib neeg, nrog cov pov thawj muaj zog tshaj plaws tshwm sim hauv cov ntsiab lus ntawm kev mob qog noj ntshav prostate.

Cov ntaub ntawv tseeb tshaj plaws yog los ntawm txoj kev tshawb fawb Phase II (NCT01681823) hauv cov txiv neej uas tsis yog - metastatic biochemically relapsed prostate cancer. Kev tshuaj xyuas thawj zaug tom qab 6 lub hlis ntawm kev kho mob nrog PectaSol-C® MCP (4.8g TID) pom tias 76% ntawm cov neeg mob tsis muaj kab mob.²²Lub sijhawm ntev - ua raws- nce ntawm 18 lub hlis yog qhov tshwj xeeb, ua kom pom cov lus teb ruaj khov hauv 85% ntawm pawg neeg sib koom, nrog rau 90% qhia qhov kev nce siab hauv PSADT.²³

Thoob plaws txhua qhov kev sim tshuaj, MCP tau pom tias muaj kev nyab xeeb zoo heev. Nws feem ntau lees paub tias muaj kev nyab xeeb (GRAS) thiab ua tau zoo - zam. Tsis muaj kev kho mob qib 3 lossis 4-txog toxicity tau raug tshaj tawm. Cov xwm txheej uas tshwm sim feem ntau yog mob me me thiab ntu ntu ntawm qib 1 mob plab, xws li flatulence, cramping, lossis raws plab.²²

Muaj peev xwm nyob rau hauv Adjuvant Settings thiab Mitigating Chemo-Toxicity

Cov ntaub ntawv kho mob ua ntej qhia tias MCP qhov kev siv hluav taws xob tuaj yeem txuas ntxiv mus rau nws cov kev tiv thaiv ncaj qha -metastatic cuam tshuam rau hauv qhov chaw kho mob.Hauv vitroCov kev tshawb fawb tau pom tias muaj kev sib koom ua ke ntawm MCP thiab cov tshuaj siv tshuaj khomob zoo li doxorubicin, ua rau muaj kev txhim kho cytotoxicity hauv cov kab mob qog noj ntshav prostate.¹¹Los ntawm inhibiting Gal-3 lub zog tiv thaiv-apoptotic muaj nuj nqi, MCP tuaj yeem txo qhov pib rau kev kho tshuaj khomob-induced cell tuag, muaj peev xwm rov ua kom cov qog resistant.²⁵

Tsis tas li ntawd, MCP tau ua kom pom lub cev tseem ceeb -cov khoom tiv thaiv. Hauv tus qauv tsiaj ntawm methotrexate-induced toxicity, MCP co-kev tswj hwm tau ua kom muaj kev puas tsuaj rau lub siab thiab ntsws. Qhov kev tiv thaiv no tau kho los ntawm kev txo qis ntawm Gal-3/TLR-4/NF-κB/TNF- inflammatory signaling pathway thiab upregulation ntawm Nrf2 antioxidant teb txoj kev.²⁶Qhov no qhia txog lub luag haujlwm muaj peev xwm rau MCP hauv kev txo cov tshuaj lom neeg lub nra ntawm kev kho mob qog noj ntshav, ib qho kev txhawj xeeb loj hauv kev kho mob.

Kev nrhiav chaw kho mob -Qib Compound: Qhov Tseem Ceeb ntawm Kev Tsim Qauv

Cov teebmeem kev kho mob ntawm MCP yog qhov tseem ceeb nyob ntawm nws cov yam ntxwv tshwj xeeb, xws li qhov hnyav molecular (MW) thiab qib ntawm esterification (DE), uas yog txiav txim los ntawm cov txheej txheem tsim khoom.⁸Qhov sib txawv tseem ceeb ntawm cov khoom lag luam muag tuaj yeem ua rau cov txiaj ntsig tsis sib xws. Yog li ntawd, rau cov kws kho mob txiav txim siab MCP raws li ib feem ntawm kev sib koom ua ke, nrhiav qhov zoo-tus yam ntxwv, kev kho mob- qib khoom yog qhov tseem ceeb rau kev kwv yees tau.

Zhejiang Kub Kropn Biotechnology Co., Ltd.yog lub teb chaws siab -tech enterprise uas ncaj qha hais txog qhov kev xav tau ntawm kev kho mob. Lawv txoj kev mob siab rau kev tshawb fawb, pom los ntawm kev koom tes nrog cov koom haum ua haujlwm xws li Zhejiang University, ua kom muaj pov thawj -raws li txoj hauv kev rau kev txhim kho cov khoom [User Query]. Los ntawm kev siv cov thev naus laus zis enzymatic hydrolysis nyob rau hauv GMP- qhov chaw muaj ntawv pov thawj, Kub Kropn ua rau siab - purity MCP nrog cov lus qhia meej molecular uas xav tau rau kev ua haujlwm bioavailability thiab kev kho mob zoo. Qhov kev cog lus rau kev ua tau zoo thiab sib xws ua rau lawv cov khoom lag luam muaj kev ntseeg siab thiab kev tshawb fawb zoo rau cov kws kho mob sib koom ua ke.

Xaus rau tus kws qhia kev sib koom ua ke

Hloov Kho Citrus Pectin yog ib qho kev nyab xeeb, zoo - zam, hais lus Gal-3 antagonist nrog lub cev muaj zog ntawm cov pov thawj preclinical thiab kev kho mob uas txhawb nqa nws lub luag haujlwm hauv oncology. Nrog rau cov ntaub ntawv cog lus hauv kev mob qog noj ntshav prostate thiab lub zog muaj txiaj ntsig zoo rau nws siv hauv inhibiting metastasis thiab muaj peev xwm txo tau cov tshuaj lom neeg muaj feem cuam tshuam rau kev kho mob, MCP sawv cev rau cov cuab yeej tseem ceeb rau cov kws kho mob sib koom ua ke.

Rau cov kev qhia tshwj xeeb, nkag mus rau cov ntaub ntawv tshawb fawb, lossis nug txog peb qhov chaw kho mob -qib Hloov Kho Citrus Pectin, thov hu rau peb pab neeg tshawb fawb ntawmwilson@zjgykp.com.

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