Cov anti-cancer muaj txiaj ntsig ntawmHloov Citrus Pectin (MCP)yog intrinsically txuas rau nws cov teeb meem teeb tsa. Lub ntujpedin-a high-molecular-hnyav heteropolysaccharide-yog hloov kho ntawm cov kua qaub / alkaline hydrolysis lossis kev kho kom zoo rau cov txiaj ntsigMcptawg nrog txo cov roj av roj (<20 kDa) and low esterification. This transformation unlocks bioavailability and bioactivity unattainable by its native pedincounterpart, uaMcpTus neeg sib tw siab rau cov ntawv thov kho.
Zhejiang kub kropn biotechnology Co., Ltd. yog National High Enterprise Kev Tshawb Fawb Kev Tshawb Fawb, ntau lawm, thiab kev muag khoom. Hauv kev koom tes nrog cov tuam txhab kev kawm xws li Zhejian University, Tianjin University, thiab Xinxian University, thiab Xinxiang Health cov khoom noj kev noj qab haus huv Nws cov khoom yog xa tawm rau ntau lub teb chaws thiab cheeb tsam cheeb tsam thoob ntiaj teb.
Hloov Citrus pectin (MCP) raug lees paub tias yog cov khoom noj muaj kev nyab xeeb ntawm cov khoom noj ntxiv (ADI)
Lub tuam txhab ua haujlwm rau 100,000-qib GMP-cov ntaub ntawv muaj ntawv pov thawj tsim khoom txiv qaub ua raw khoom siv thiab ua haujlwm siab tshaj hydrolyly hydroxysis siv cov high-purity mcp. Txhua kauj ruam ntawm cov txheej txheem - los ntawm raw cov khoom siv rau kev tsim khoom rau kev tsim-yog nruj me ntsis tswj. Lub tuam txhab ua cov khoom xyaw rau cov khoom xyaw ntuj thiab cov txheej txheem kev ntxuav kom huv ntau yam kom ntseeg tau tias cov khoom muaj kev nyab xeeb thiab kev nyab xeeb zoo dua.
Cov qauv kev txiav txim siab tseem ceeb ntawm MCP:
Molecular hnyav (MW):
Tawg tawg<20 kDa penetrate tissues and enter circulation, while larger pedinPolymers nyob twj ywm rau lub plab. Mw kuj cuam tshuam cov tshuaj tua cov tshuaj;McpFragments ~ 10-15 KDA Qhia Txog Cov Lus Qhia Txog Kev Ua Kom Zoo Raws Li Qhov Lawv Sib Tsig ntawm Kev Ua Kom Haum thiab Phiaj Los Ntawm Lub Hom Phiaj.
Qib ntawm Esterification (de):
Tsawg (<10%) in McpTxheeb cov pab pawg Carboxyl, txhim kho solubility thiab tuav rau gal-3's carbohydrate lees paub sau npe (CRD). Qhov kev sib piv nrog High-depedin, uas tsis muaj qhov kev ua phem no.
RG-Kuv sau:
Lub rhhamngalacturonan-i (rg-i) cheeb tsam hauvMcpMuaj -1,4-galactan sab chains terminating nyob rau hauv galactose hauv galactose hauv galactose, lub xub pharmacophorore rau gal-3 inhibition. Cov qauv txheem no tshwj xeeb tsis muaj qhov tsis txaus ntseegpedin.
Terminal Monosaccharides:
Galactose seem nyob rau hauvMcpyog qhov tseem ceeb rau gal-3 ib qho. Kev nyob ib sab arabinose lossis xylose cov seem txuas ntxiv kho qhov tshwj xeeb, zoo-khoMcpKev sib cuam tshuam nrog cov kab mob cancer ntsig txog kev cuam tshuam.
Tus qauv-kev ua si sib raug zoo (SAR):
MCP's Galactan-nplua nuj tawg(piv txwv li, mcp-m) khi gal-3 ntau dua li tsis sib xwspedin, ua pov thawj qhov tseem ceeb ntawm cov tshuaj hydrolysis.
Homogalacturonan (HG) caj qaum hauvMcpTxhab tes galactan conformation, ua kom muaj kev sib cav sib ceg rau gal-3-ib lub tshuab uas nthuav tawm kev txwv.
Cov suab thaj unsaturated tsim tawm thaum tshav kub hloov kho ntawmpedin(piv txwv li, HTCP) yuav ua rau apoptosis ntawm nws tus kheej ywj pheej ntawm gal-3, tawm tswv yim tiv thaiv cov kab mob cancer ntxiv rau kev ua kom zooMcpCov variants.
Cov nyom Bioavility:
ThaumMCP'sHydrophilicity txwv sab hauv, nws cov MW MW TsawgpedinCov. Passive diffusion tshwm sim, tab sis nquag thauj khoom ntawm cov receptors (piv txwv li, asgp-r nyob rau hepatocytes) yog cov. Nyob qho nruab nrabMcpCov zauv hla caco-2 cov monolayers ntau dua li cov acidic, hais txog lub luag haujlwm ntawm kev ua kom haum hauv kev tsim kho.
Cov Lus Qhia Yav Tom Ntej:
Microheterogeneity:
MCP'scov qauv hloov pauv hloov pauv kev txhim kho tshuaj. Cov tswv yim zoo li DEACHOLULIBE-Cellulose chromatographaphy tuaj yeem tawm tau ntau yampectin-derivedbatches.
Khoom cua Analogs:
Kev ua haujlwm siv tshuaj lom neeg malactoolaccharides mimickingMCP'sTerminal Galactose tuaj yeem txhim kho homogeneity thiab tshuaj zoo li qub thaum khaws cov kab mob bioactivity.
Xaus:
Tus Qauv Tsim ntawmMcpFragics-optimizing galacue qhov ntom, mw, thiab them nqi-yog qhov tseem ceeb rau kev nce qib hauv Gran-3-hom kev kho mob. Los ntawm kev nce qib cov txheej txheem tshwj xeeb zoo ntawmMcpTshaj tawmpedin, Cov kws tshawb nrhiav tuaj yeem tsim cov neeg sawv cev hauv ntej-cancer hauv cov neeg mob cancer nrog kev ua kom zoo dua thiab kev ua tau zoo.